Segregation of aging determinants during asymmetric cell division
Abstract: Asymmetric cell division provides a means for partitioning not only cell fate determinants but also determinants of cellular age. Increasing evidence suggests that stem cells employ such mechanism for continual maintenance of high proliferative potential. The budding yeast provides an outstanding single-cellular eukaryotic model for study asymmetric aging. Each division cycle of yeast produces a new born bud and an aged mother cell. Two types of aging determinants are segregated asymmetrically: beneficial components that slowly deteriorate but are scarcely replenished, and toxic components that accumulate as a result of acute or chronic cellular stress. Different cellular mechanisms have been discovered to govern the partitioning of these aging determinants. In addition, cellular organelles such as mitochondria playpreviously unknown roles in cellular quality control and aging.
Bio: Rong Li graduated from Yale with combined BS and MS in Molecular Biophysics and Biochemistry. After Ph.D. at UCSF and postdoc at UC Berkeley, she became Assistant Professor at Harvard Medical School in 1994 and was later promoted to Associate Professor. She was recruited to Stowers Institute as Investigator in 2005. In 2015, Rong Li came to Johns Hopkins as Bloomberg Distinguished Professor with joint appointments in the Department of Cell Biology and the Department of Chemical and Biomolecular Engineering. She is also Director of Center for Cell Dynamics in Institute of Basic Biomedical Sciences. Rong Li takes an interdisciplinary approach to study the biology of the cell and has made seminal discoveries in mitosis regulation, cell polarity, cytoskeleton dynamics, and cellular evolution.